Information and Communication Technology has permeated every walk of life impacting technology fields such as launching satellites, managing businesses across the globe and enabling social networking. The convergence of computer, communication and content technologies, known as ICT, has drawn the attention of the academia, business, government and communities to use it for innovative profitable propositions. The syllabus of Informatics Practices has been revisited accordingly with focus on generic concepts with domain-specific practical experiments and projects to ensure conceptual knowledge with practical skills. This book, Informatics Practices with Python for Class XI (065), has been prepared in accordance with the latest CBSE syllabus for the 2025-26 academic session. The book focuses on teaching Python language, including programming concepts, problem-solving skills, introductory NumPy for numerical computing and RDBMS operations for efficient database management. With easy-to-understand examples, self-explanatory diagrams and other such tools, the student learns to design the logic for a program and then implement that program using Python. Besides tested, debugged and error-free codes with screenshots, ample concise and practical example programs derived from real-life situations have been provided in the book. CTM (Commit to Memory), Learning Tips and Points to Remember for easy recall of important terms and concepts are other notable features of the book.